Desde hace mucho tiempo, se sabe que nuestros cuerpos son anfitriones de una gran cantidad y variedad de microbios, algunos esenciales para nuestra existencia. Se cree que tenemos un tercio más de estas formas de vida en nuestro cuerpo que de propias células humanas. Podríamos pensar que lo tenemos todo controlado, y somos capaces de saber cuándo estos pequeños seres nos ayudan y cuando incordian, pero no: resulta que más del 99% de los microbios dentro de nosotros son totales desconocidos para la ciencia.
|
etiquetas: microbios , ciencia 
Numerous uncharacterized and highly divergent microbes which colonize humans are revealed by circulating cell-free DNA
Apariciones de "99%" en el articulo original:
Cero
Entonces, ¿qué dice el artículo original?
Blood circulates throughout the human body and contains molecules drawn from virtually every tissue, including the microbes and viruses which colonize the body. Through massive shotgun sequencing of circulating cell-free DNA from the blood, we identified hundreds of new bacteria and viruses which represent previously unidentified members of the human microbiome. Analyzing cumulative sequence data from 1,351 blood samples collected from 188 patients enabled us to assemble 7,190 contiguous regions (contigs) larger than 1 kbp, of which 3,761 are novel with little or no sequence homology in any existing databases. The vast majority of these novel contigs possess coding sequences, and we have validated their existence both by finding their presence in independent experiments and by performing direct PCR amplification. When their nearest neighbors are located in the tree of life, many of the organisms represent entirely novel taxa, showing that microbial diversity within the human body is substantially broader than previously appreciated.
El artículo está bien y no tiene ningún error de bulto. El error está en el becario de nmas1.org que se ha sacado el titular de la manga.
No hace falta que me des las gracias.
¿Qué dice el articulo original?
We sequenced a total of 37 billion molecules from the 1,351 samples of cfDNA, of which 95% of reads passed quality control. Of these, an average of 0.45% did not align to the reference human genome (GRCh38) (Fig. 1A, Left), in line with our expectations of the nonhuman DNA sources in the body. Of these putatively nonhuman reads, only approximately 1% could be identified in a curated microbiome database of almost 8,000 species of known bacteria, viruses, fungi, and eukaryotic pathogens (Fig. 1B, Left). This miniscule fraction of reads encompasses the known microbiome. Less than 1,800 known species (800 known genera) are observed across all samples. The rarefaction curve of species prevalence quickly plateaus, and the species abundance distribution has only a slight positive skew (SI Appendix, Fig. S1). These both indicate that the number of known species we measure has saturated (20), and deeper or broader sequencing of cfDNA from humans is unlikely to substantially increase the richness of known species.
El artículo está bien y no tiene ningún error de bulto. El error tampoco está en el becario de nmas1.org.
Ahora me pregunto, ¿has leído por completo el artículo?. Dale, ahora tómate tu tiempo. Lee algo más que el abstract.
Así que no le des más vueltas. Errónea, irrelevante... elije tú mismo.
Un dato importante: 100-1=99